Phase I/II trial of formoterol fumarate combined with megestrol acetate in cachectic patients with advanced malignancy
نویسندگان
چکیده
منابع مشابه
Phase I trial of paclitaxel plus megestrol acetate in patients with paclitaxel-refractory ovarian cancer.
Increased expression of P-glycoprotein has been proposed as one important mechanism for inherent or acquired drug resistance of malignant disease to cytotoxic chemotherapy. In experimental systems, hormonal agents, including megestrol acetate (MA), have been shown to be capable of reversing P-glycoprotein-mediated multidrug resistance to natural products, including paclitaxel. Because paclitaxe...
متن کاملActivity of megestrol acetate in postmenopausal women with advanced breast cancer after nonsteroidal aromatase inhibitor failure: a phase II trial.
BACKGROUND As novel treatments carry substantial price tags and are mostly cost-prohibitive in low- and middle-income countries, there is an urgent need to develop alternatives, such as off-patent drugs. Megestrol acetate (MA) has a longstanding history in the treatment of breast cancer, but recently it is being used less often due to the advent of newer agents. PATIENTS AND METHODS This two-...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Supportive Care in Cancer
سال: 2014
ISSN: 0941-4355,1433-7339
DOI: 10.1007/s00520-013-2081-3